Author

I. Hers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. W. Poole· 4 shared C. M. Williams· 2 shared K. J. Heesom· 2 shared L. J. Goudswaard· 2 shared S. F. Moore· 2 shared S. J. Mundell· 2 shared X. Zhao· 2 shared A. D. Davidson· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCell Biology

A. W. Poole

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CryoET reveals actin filaments within platelet microtubules

C. Tsuji, M. Bradshaw, M. Allen, M. L. Jackson, J. Mantell, U. Borucu, A. W. Poole, P. Verkade, I. Hers, D. M. Paul, M. Dodding

The paper uses cryoET to show cofilin-bound F-actin within platelet microtubules, revealing physiological actin-microtubule hybrids formed under mechanical stress.

bioRxiv · Nov 24, 2023Cell Biology

Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19

L. J. Goudswaard, C. M. Williams, J. Khalil, K. L. Burley, F. Hamilton, D. Arnold, A. Milne, P. A. Lewis, K. J. Heesom, S. J. Mundell, A. D. Davidson, A. W. Poole, I. Hers

This study identifies altered platelet proteome and impaired integrin αIIbβ3 activation in COVID-19 patients, linked to increased platelet-neutrophil aggregates and thromboinflammation.

bioRxiv · Oct 12, 2022 · PreprintCell Biology

Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function and thrombosis.

J. S. Trory, A. Munkacsi, K. Sledz, L. J. Goudswaard, K. J. Heesom, S. F. Moore, B. Nabet, V. K. Aggarwal, I. Hers

This study shows that chemical degradation of BTK/TEC in human platelets reduces thrombotic function without affecting PAR-1-mediated responses.

bioRxiv · May 30, 2022 · PreprintCell Biology

Platelet generation from circulating megakaryocytes is triggered in the lung vasculature

X. Zhao, D. Alibhai, T. G. Walsh, N. Tarassova, S. Z. Birol, C. M. Williams, C. R. Neil, E. W. Aitken, A. K. Waller, J. Ballester-Beltran, P. W. Gunning, E. C. Hardeman, E. O. Agbani, I. Hers, C. Ghevaert, A. W. Poole

The paper shows that megakaryocytes generate large numbers of platelets intravascularly in the lung, dependent on oxygenation, endothelium, and TPM4.

bioRxiv · Nov 1, 2021 · PreprintPhysiology

A role for SHARPIN in platelet linear protein ubiquitination and function

S. F. Moore, X. Zhao, S. Mallah, A. W. Poole, S. J. Mundell, J. L. Hutchinson, I. Hers

This study shows that SHARPIN is essential for platelet linear ubiquitination and function, particularly in responses to CRP and U46619, with impaired thrombosis in SHARPIN-deficient mice.

bioRxiv · Jan 13, 2021 · PreprintCell Biology