Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota
L. Hoyles, M. L. Jimenez-Pranteda, J. Chilloux, F. Brial, A. Myridakis, T. Aranias, C. Magnan, G. R. Gibson, J. D. Sanderson, J. K. Nicholson, D. Gauguier, A. L. McCartney, M.-E. Dumas
The paper demonstrates that gut microbiota can convert trimethylamine N-oxide (TMAO) back to trimethylamine (TMA), which is then absorbed by the host and reconverted to TMAO, highlighting a metabolic retroconversion process.
bioRxiv · Mar 27, 2018Microbiology