Optimized cell culture conditions promote ex-vivo manipulation and expansion of primitive hematopoietic stem cells for therapeutic gene editing.
R. Rai, W. Vetharoy, A. Naseem, Z. Steinberg, A. J. Thrasher, G. Santilli, A. Cavazza
This study optimizes ex-vivo culture conditions to enhance gene editing efficiency in primitive hematopoietic stem cells while preserving their stemness and enabling expansion.
bioRxiv · Jan 11, 2022 · PreprintBioengineering