R. Rai

Chemically induced partial unfolding of the multifunctional Apurinic/apyrimidinic endonuclease 1

This study investigates how the redox inhibitor APX3330 induces reversible partial unfolding of APE1, revealing structural changes relevant to its redox function.

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

Characterisation and comparison of semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility

This study compares semen microbiota and sperm function in men with infertility, recurrent miscarriage, or proven fertility, finding no overall association but highlighting Flavobacterium's potential role.

Understanding inter-individual social networks in mixed-species bird flocks

This study constructs individual-level social networks in mixed-species bird flocks in the Eastern Himalaya, revealing differences in flock structure and mechanisms between two flocktypes.

Optimized cell culture conditions promote ex-vivo manipulation and expansion of primitive hematopoietic stem cells for therapeutic gene editing.

This study optimizes ex-vivo culture conditions to enhance gene editing efficiency in primitive hematopoietic stem cells while preserving their stemness and enabling expansion.

β-Catenin-NFκB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

This study identifies a β-catenin-NFκB-CFTR interactome in cholangiocytes that regulates inflammation and fibrosis during ductular reaction in liver disease.

Temporal transcriptional response of Candida glabrata during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and drug resistance

The paper maps transcriptional responses of Candida glabrata during macrophage infection and identifies CgXbp1 as a key regulator of virulence and drug resistance.

OsbZIP47 an integrator for meristem regulators during rice plant growth and development

OsbZIP47 regulates rice shoot meristem size, panicle and floret development in concert with other meristem regulators such as OsMADS1, RFL and OSH1.

Spelling changes and fluorescent tagging with prime editing vectors for plants

This paper develops and validates prime editing vectors for plants, enabling large insertions and fluorescent tagging in dicots and monocots.

Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells

This study shows that WASp deficiency impairs autophagy and mitochondrial function in human myeloid cells, with ARP2/3 dependency and metabolic consequences.

A strain of an emerging Indian pathotype of Xanthomonas oryzae pv. oryzae defeats the rice bacterial blight resistance gene xa13 without inducing a clade III SWEET gene and is nearly identical to a recent Thai isolate

The paper identifies an Xoo strain that bypasses xa13 resistance by not inducing clade III SWEET genes and is nearly identical to a Thai isolate.

Epigenetic analysis identifies factors driving racial disparity in prostate cancer

The paper analyzes epigenetic differences between African American and Caucasian prostate cancer patients to identify factors contributing to racial disparities in disease aggressiveness and outcomes.