MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species
E. Roider, A. I. T. Lakatos, A. M. McConnell, P. Wang, A. Mueller, A. Kawakami, J. Tsoi, B. L. Szabolcs, A. A. Ascsillan, Y. Suita, V. Igras, J. A. Lo, J. J. Hsiao, R. Lapides, D. M. P. Pal, , D. E. Fisher
The paper shows MITF promotes melanoma survival by increasing resistance to reactive oxygen species through regulating antioxidant genes like IDH1 and NNT.
bioRxiv · Nov 10, 2023 · PreprintCancer Biology