A. Mueller

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

Locally released somatostatin triggers cAMP and Ca2+ signaling in primary cilia to modulate pancreatic β-cell function

This study shows that somatostatin acting on primary cilia of pancreatic β-cells modulates cAMP and Ca2+ signaling, affecting β-cell function and linking cilia length to type-2 diabetes.

Multi-omics data integration reveals molecular mechanisms of carfilzomib resistance in multiple myeloma

This study identifies molecular mechanisms of carfilzomib resistance in multiple myeloma using multi-omics data from cell lines and patient samples, revealing potential drug combinations to overcome resistance.

MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species

The paper shows MITF promotes melanoma survival by increasing resistance to reactive oxygen species through regulating antioxidant genes like IDH1 and NNT.

Dynamic ventral disc contraction is necessary for Giardia attachment and host pathology

This study shows Giardia's ventral disc contracts during attachment, causing host cell damage, and identifies three contraction types that reduce disc size.

The domed architecture of Giardias ventral disc is necessary for attachment and host pathogenesis

This study shows that Giardia's ventral disc, shaped by MBP, is essential for attachment and causing host epithelial barrier damage.

OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

The paper shows OSBP-mediated lipid exchange at ER-secretory granule contacts regulates insulin secretion by controlling cholesterol levels and is influenced by PI(4)P, VAPs, and Sac2.

Lidocaine Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Cells Through Activation of Bitter Taste Receptor T2R14

This study shows lidocaine activates T2R14 in HNSCC cells, leading to apoptosis via mitochondrial depolarization, ROS production, and proteasome inhibition.

Transcriptional and clonal characterization of cytotoxic CD8+ T cells in crescentic glomerulonephritis

This study identifies clonally expanded cytotoxic CD8+ T cells in ANCA-associated cGN and shows their pathogenic role in kidney disease progression.

Accessibility and Reproducible Research Practices in Cardiovascular Literature

This study assesses reproducibility and accessibility in cardiovascular research by analyzing 400 articles, finding less than 2% provide sufficient resources for reproducibility.

T32 training is associated with increased likelihood of obtaining an academic research faculty position: a cross-sectional study

This study finds that T32 trainees are more likely to become research faculty compared to non-T32 trainees, but face challenges like instability and competition in academia.

Food interactions observed in a pharmacokinetic investigation comparing two marketed cold preparations (BNO1016 and ELOM-080) after administration to male beagle dogs

This study compares the pharmacokinetic effects of two cold remedies, BNO1016 and ELOM-080, under fasting and fed conditions in beagle dogs, finding no food effect for BNO1016 but significant food effects for ELOM-080.

Convergent use of phosphatidic acid for Hepatitis C virus and SARS-CoV-2 replication organelle formation

This study identifies phosphatidic acid as critical for double membrane vesicle formation in HCV and SARS-CoV-2 replication, suggesting host-targeted PA synthesis inhibition as a therapeutic strategy.

Lytic infection with murine gammaherpesvirus 68 activates host and viral RNA polymerase III-dependent promoters to enhance non-coding RNA expression

This study shows that gammaherpesvirus 68 infection increases host and viral RNA polymerase III promoter activity, leading to enhanced non-coding RNA expression.

Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model

This study shows that male golden Syrian hamsters experience more severe lung disease and lower antiviral antibody responses compared to females after SARS-CoV-2 infection.

Bacterial galactosemia is caused by cytoplasmic interference of an essential cell wall biosynthesis glycosyltransferase

This study identifies the mechanism of bacterial galactosemia, showing that galactose interferes with MurG, an essential glycosyltransferase, leading to cell wall biosynthesis inhibition and cell death.

3D FIB-SEM reconstruction of microtubule-organelle interaction in whole primary mouse beta cells

The paper provides 3D reconstructions of microtubule networks in primary mouse beta cells and shows their role in insulin secretory granule positioning.

Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

This study develops a mouse model of TNBC that recapitulates human tumor heterogeneity and identifies a synergistic combination of WEE1 and BCL-XL inhibition as a potential treatment.

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.

Preserving Vascular Integrity Protects Mice Against Multidrug-Resistant Gram-Negative Bacterial Infection

This study shows that inhibiting ARF6 protects mice from MDR Gram-negative bacterial infections by preserving vascular integrity.

A Cell Proliferation and Inflammatory Signature is Induced by Lawsonia intracellularis Infection in Swine

This study identifies a cell proliferation and inflammatory signature induced by Lawsonia intracellularis infection in swine through transcriptomic analysis of intestinal tissue.