Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants
A. Neamtu, F. Mocci, A. Laaksonen, F. L. Barroso da Silva
The paper uses a multiscale computational protocol to design mAbs with higher binding affinity to SARS-CoV-2 spike protein RBD across variants, identifying candidates with improved performance against Omicron.
bioRxiv · Jan 4, 2022Biophysics