Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping.
G. Foran, R. D. Hallam, M. Megaly, A. Turgambayeva, D. Antfolk, Y. Li, V. C. Luca, A. Necakov
This study shows that Notch1's N1ICD forms transcriptional condensates via phase separation coupled percolation, enhancing target gene expression and enhancer looping.
bioRxiv · Mar 17, 2023Cell Biology