Y. Li

A Thermo-responsive collapse system for controlling heterogeneous cell localization, ratio and interaction for three-dimensional solid tumor modeling

The paper introduces TheCOS, a thermo-responsive system for creating 3D tumor models with controlled cell localization and interactions, demonstrating its use in studying NK cell cytotoxicity in solid tumor environments.

Dynamic, single-cell monitoring of CAR T cell identity and activation with Raman spectroscopy

Gold-nanorod surface-enhanced Raman spectroscopy with LightGBM separates CAR T from untransduced T cells, tracks antigen-specific activation dynamics, and discriminates sorted CAR+ from CAR- patient T cells.

Compartmentalized cytokine networks and systemic immune remodeling in bovine mammary H5N1 infection.

This study investigates immune responses in bovine mammary glands infected with H5N1, finding compartment-specific cytokine networks and systemic immune changes.

Endothelial PTBP1 Deletion in Transplanted Cardiac Tissue Limits Cardiac Allograft Vasculopathy

This study identifies PTBP1 as a key regulator of endothelial dysfunction in cardiac allograft vasculopathy, showing its deletion reduces fibrosis and immune activation in mouse models.

An AI/ML-Powered Workflow for End-to-End Cell Line Development

This paper develops a deep learning tool for automating cell line development, achieving a 36-day workflow for generating high-titer antibody-producing cell lines.

Mycn regulates vascular development through PI3K signaling pathway in zebrafish

This study shows Mycn regulates vascular development in zebrafish by promoting cell proliferation and that PI3K signaling can rescue vascular defects caused by Mycn deficiency.

The atypical antidepressant and cognitive enhancer tianeptine disinhibits hippocampal CA1 pyramidal neurons by reducing GABAergic neurotransmission

This study investigates tianeptine's effects on hippocampal CA1 neurons, showing it reduces GABAergic neurotransmission and disinhibits pyramidal neurons, but not through simple GABA blockade.

Identifying differential effects from eleven mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance

The paper compares the effects of eleven mixing techniques on mRNA lipid nanoparticle physicochemistry and biological performance, finding significant differences in particle properties and performance across methods.

Effect of exportin 1/XPO1 nuclear export pathway inhibition on coronavirus replication.

This study investigates how inhibiting the XPO1 nuclear export pathway affects coronavirus replication in different cell lines, finding varied effects on MHV and SARS-CoV-2.

Spheroplasted cells: a game changer for DNA delivery to diatoms

This paper develops optimized DNA delivery methods for diatoms, enabling efficient transformation and genome engineering.

Preparation of oxygen-sensitive proteins for high-resolution cryoEM structure determination using (an)aerobic blot-free vitrification

This paper presents a streamlined method for (an)aerobic vitrification of oxygen-sensitive proteins using an automated device, enabling high-resolution cryoEM structure determination.

A distant TANGO1 family member promotes vitellogenin export from the ER in C. elegans

This study identifies TNGL-1 as a C. elegans TANGO1 family member that facilitates vitellogenin export from the ER by engaging cargo via a luminal domain.

Mixtures of Intrinsically Disordered Neuronal Protein Tau and Anionic Liposomes Reveal Distinct Anionic Liposome-Tau Complexes Coexisting with Tau Liquid-Liquid Phase Separated Coacervates

This paper investigates the interactions between tau protein and anionic liposomes, revealing distinct complexes and phase-separated coacervates under varying ionic conditions.

Origin and stepwise improvement of vertebrate lungs

The paper analyzes single-cell RNA sequencing data to show that lung development involves regulatory changes and new genes, with some features specific to bony fishes and mammals.

Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

This study shows that Lacticaseibacillus rhamnosus P118 enhances host resistance to Salmonella by promoting indole metabolites from gut microbes.

Modulating Mesenchymal Stromal Cell Microenvironment Alters Exosome RNA Content and Ligament Healing Capacity

This study shows that altering the microenvironment of mesenchymal stromal cells changes exosome RNA content and improves ligament healing in rats.

Interspecies interaction reshapes the fitness landscape of evolved genotypes

This study investigates how interspecies interactions shape genetic and phenotypic diversity in a two-species microbial consortium over evolutionary time.

MAP4K1 and MAP4K2 regulate ABA-induced and Ca2+-mediated stomatal closure in Arabidopsis

This study identifies MAP4K1 and MAP4K2 as regulators of ABA-induced and Ca2+-mediated stomatal closure in Arabidopsis through phosphoproteomic and functional analyses.

Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicry

This study identifies a gut microbiome-derived peptide that mimics a myelin antigen and induces experimental autoimmune encephalomyelitis in mice.

Mutation of phosphatidate phosphohydrolase genes confers broad-spectrum disease resistance in plants

The paper shows that mutating phosphatidate phosphohydrolase (PAH) genes in rice and Arabidopsis increases phosphatidic acid (PA) levels and broad-spectrum disease resistance.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

Colicin Receptor CirA Enhances Salmonella Typhimuriums Resistance to Colicin Ib in the Absence of the Cognate Immunity Protein

This study identifies CirA as a colicin receptor that enhances resistance to ColIb in S. Typhimurium despite lacking the immunity protein.

B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1

This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.

Dynamic Human Gut Microbiome and Immune Shifts During an Immersive Psychosocial Therapeutic Program

The paper examines microbiome and immune changes in depression during a psychosocial intervention, finding a protective role for Prevotella-dominant microbiomes and reduced inflammation.

CCDC32 stabilizes clathrin-coated pits and drives their invagination

This study identifies CCDC32 as an endocytic accessory protein that stabilizes clathrin-coated pits and drives their invagination, with mutations linked to cardio-facio-neuro-developmental syndrome.

A family of lanthipeptides with anti-phage function

The paper identifies a family of over 2000 lanthipeptide biosynthetic gene clusters in Actinobacteria with anti-phage function, demonstrating their conservation and novel compound production.

A Combination of Machine Learning and PBPK Modeling Approach for Pharmacokinetics Prediction of Small Molecules in Humans

This paper combines machine learning and PBPK modeling to predict small molecule pharmacokinetics in humans without experimental data, achieving higher accuracy than traditional methods.

Reduced Auditory Perception and Brain Response with Quiet TMS Coil

This study compares the stimulation strength, perceived loudness, and EEG response between a quiet TMS coil (qTMS-DCC) and a conventional TMS coil, finding the qTMS-DCC is quieter and produces smaller auditory-evoked potentials.

Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.