Author

A. Obr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Grebenova· 3 shared K. Kuzelova· 3 shared A. Holoubek· 2 shared B. Brodska· 2 shared P. Roselova· 2 shared D. Myslivcova· 1 shared H. Klamova· 1 shared J. Brezinova· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

D. Grebenova

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Inhibition of Casein Kinase 2 induces cell death in chronic myelogenous leukemia cells resistant to tyrosine kinase inhibitors

O. Mitrovsky, D. Myslivcova, T. Machackova-Lopotova, A. Obr, K. Cermakova, S. Ransdorfova, J. Brezinova, H. Klamova, M. Zackova

This study shows that inhibiting Casein Kinase 2 (CK2) induces cell death in chronic myelogenous leukemia (CML) cells resistant to tyrosine kinase inhibitors (TKIs) and may enhance TKI efficacy.

bioRxiv · Jun 28, 2021Cancer Biology

PAK1 and PAK2 in cell metabolism regulation

T. Koranova, L. Dvoracek, D. Grebenova, P. Roselova, A. Obr, K. Kuzelova

This study investigates the role of PAK1 and PAK2 in cell metabolism by analyzing their impact on mitochondrial respiration and glycolysis in various cell lines.

bioRxiv · May 18, 2021Cell Biology

Group I p21-activated kinases in leukemia cell adhesion to fibronectin

K. Kuzelova, A. Obr, P. Roselova, D. Grebenova, P. Otevrelova, B. Brodska, A. Holoubek

This study investigates the role of PAK group I kinases in leukemia cell adhesion to fibronectin, showing differential effects of PAK inhibitors on cell behavior and survival.

bioRxiv · Aug 25, 2020Cell Biology

PAK1, PAK1Δ15, and PAK2: similarities, differences and mutual interactions

D. Grebenova, A. Holoubek, P. Röselova, A. Obr, B. Brodska, K. Kuzelova

This study compares PAK1, PAK1Δ15, and PAK2, showing PAK1Δ15 is more similar to PAK2 than PAK1-full in localization and function, with distinct roles in cell adhesion and glycolysis.

bioRxiv · Mar 18, 2019Cell Biology