Inter-subunit Crosstalk via PDZ Synergistically Governs Allosteric Activation of Proapoptotic HtrA2
A. Parui, V. Mishra, S. Dutta, P. Bhaumik, K. Bose
This study investigates how PDZ domains in HtrA2 subunits synergistically regulate allosteric activation through inter-subunit crosstalk, revealing a model of cooperative energy landscape dynamics.
bioRxiv · Oct 4, 2021Biochemistry