S. Dutta

CD44/Integrin β1 association drives fast motility on HA substrates

This study shows that CD44/Integrin β1 association enables faster cell motility on HA substrates by forming smaller, weaker focal adhesions.

Crosstalk between plasma membrane and Staphylococcus α-hemolysin during oligomerization

This study investigates the structural and functional dynamics of Staphylococcus aureus α-hemolysin during membrane interaction, revealing its role in cell necrosis and pore formation.

Co-existence of plasmid-mediated blaNDM-1 and blaNDM-5 in Escherichia coli sequence type 167 and ST101 and their discrimination through restriction digestion

This study identifies and characterizes co-existing blaNDM-1 and blaNDM-5 variants in E. coli isolates using Sanger sequencing and hybrid assembly, and develops a restriction digestion method to distinguish them.

Interplay of geometry and mechanics in epithelial wound healing

This study develops a mathematical model to predict epithelial wound healing outcomes based on geometric and mechanical properties, validated through experiments on MDCK cells.

Two distinct integrin binding sites on MMP9 drive cancer invasion by mediating integrin membrane trafficking & stabilization

Expansion microscopy reveals unique ultrastructural features of pathogenic budding yeast species

This study uses expansion microscopy to reveal unique sub-cellular structures in Candida albicans, showing a distinct SPB arrangement compared to Saccharomyces cerevisiae.

TIAM1 signaling drives prostatic budding and branching phenotypes and is a potential therapeutic target for BPH

This study identifies TIAM1-RAC1 signaling as a driver of prostatic budding and branching in BPH and suggests it as a therapeutic target.

Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation

This study shows that PfKelch13 mutants have reduced heme-binding affinity, leading to decreased artemisinin activation and contributing to artemisinin resistance.

Protein search processes mediated by chromatin topology

The paper investigates how chromatin compaction affects protein search kinetics using models and experimental data, finding optimal compaction minimizes protein residence time.

Establishment of an intragastric surgical model using C57BL/6 mice to study the vaccine efficacy of OMV-based immunogens against Helicobacter pylori

The paper establishes a surgical model in C57BL/6 mice to study OMV-based vaccine efficacy against H. pylori, showing protective immunity after immunization.

Extremely oligotrophic and complex carbon degrading microaerobic bacteria from Arabian Sea oxygen minimum zone sediments

The paper isolates and characterizes aerobic bacteria from Arabian Sea sediments, showing their ability to degrade complex organic matter under low oxygen conditions and maintain populations in oligotrophic environments.

Bacterial pore-forming toxin pneumolysin drives pathogenicity through shed toxin-loaded host extracellular vesicles

This study shows that pneumolysin-loaded host extracellular vesicles contribute to pneumococcal pathogenesis by inducing cytotoxicity and inflammation.

Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

This paper shows telomere length regulates hTERT expression by modulating TRF2 binding and PRC2-mediated repression, revealing a self-regulatory mechanism in cancer.

Potential use of Sodium Butyrate (SB) as an anti-virulence agent against Vibrio cholerae targeting ToxT virulence protein.

This paper shows sodium butyrate suppresses virulence in Vibrio cholerae by inhibiting ToxT-DNA binding and reducing toxin production, suggesting it as an anti-virulence agent.

Characterization of binding kinetics and intracellular signaling of new psychoactive substances targeting cannabinoid receptor using transition-based reweighting method

This study uses simulation and machine learning to analyze how new psychoactive substances interact with cannabinoid receptors, revealing structural differences that lead to stronger beta-arrestin signaling and adverse effects.

PDZ Domains from the Junctional Proteins Afadin and ZO-1 Act as Mechanosensors

This study shows that PDZ domains from afadin and ZO-1 act as mechanosensors, forming catch bonds or weakening under mechanical force, affecting cell-cell adhesion stability.

The Effect of Sunlight Intensity on Flower Opening Time and Exposure Duration in Rice (Oryza sativa ssp. indica) Landraces

This study examines how sunlight intensity affects flower opening time and duration in rice landraces, finding that cloudy conditions delay flowering and prolong the sunrise-to-anthesis duration.

Contrasting Effects of SARS-CoV-2 Vaccination vs. Infection on Antibody and TCR Repertoires

This study compares antibody and TCR repertoires in SARS-CoV-2 infectees, vaccinees, and controls to predict neutralizing antibody titers and identifies subtle differences in adaptive immune responses.

Colonization of larval zebrafish (Danio rerio) with adherent-invasive Escherichia coli prevents recovery of the intestinal mucosa from drug-induced colitis

This study shows that AIEC colonization in a larval zebrafish model worsens DSS-induced colitis and prevents mucosal recovery.

An amphipathic helix facilitates direct membrane binding of Mycoplasma FtsZ

This study identifies a novel amphipathic helix in mycoplasma FtsZ that enables direct membrane binding, offering insights into Z-ring constriction in cell wall-less bacteria.

Comparative metagenomic analysis of diarrheal and non-diarrheal gut microbiome delineating the prospective development of prognostic markers and probiotics to protect from diarrhea

The paper compares gut microbiomes of diarrheal and non-diarrheal samples to identify dysbiosis patterns and potential prognostic markers and probiotics for diarrhea prevention.

The gut microbiome of the healthy population in Kolkata, India, is a reservoir of antimicrobial resistance genes emphasizing the need of enforcing antimicrobial stewardship

The study detects antimicrobial resistance genes in the gut microbiome of healthy individuals in Kolkata, highlighting the need for antimicrobial stewardship.

TBX2 driven switch from Androgen Receptor to Glucocorticoid Receptor signaling confers therapeutic resistance in Prostate Cancer

This study identifies TBX2 as a molecular switch that represses AR and activates GR signaling, driving enzalutamide resistance in CRPC, and suggests SP2509 as a potential therapeutic strategy.

Myocardial IGF2R is a critical mediator of inflammation and fibrosis after ischemia-reperfusion injury

This study investigates the role of IGF2R in myocardial ischemia-reperfusion injury, finding it promotes inflammation and fibrosis and is a potential therapeutic target.

Self-organized intracellular twisters

The paper studies fluid flows in Drosophila oocytes, showing the emergence of cell-spanning vortices through hydrodynamic interactions of microtubules and molecular motors.

GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior

This study shows GD2 and its biosynthetic enzyme GD3S promote prostate cancer tumorigenesis by maintaining cancer stem cells and EMT markers.

Recognition determinants of improved HIV-1 neutralization by a heavy chain matured pediatric antibody

This study characterizes a matured HIV-1 broadly neutralizing antibody from a pediatric donor, showing improved neutralization breadth and potency through structural analysis.

Cryo-EM reveals the mechanism of DNA compaction by Mycobacterium smegmatis Dps2

This study uses cryo-EM to reveal how MsDps2 binds and compacts DNA, identifying key arginine residues involved in DNA binding and lattice formation.

High resolution cryo-EM structures of two potently SARS-CoV-2 neutralizing monoclonal antibodies of same donor origin that vary in neutralizing Omicron variants

The paper presents high-resolution cryo-EM structures of two SARS-CoV-2 neutralizing mAbs from the same donor, showing differences in their binding to Omicron variants and conformational changes in the spike protein.

Dynamics of interdomain rotation facilitates FtsZ filament assembly

This study investigates FtsZ assembly dynamics by analyzing SmFtsZ from Spiroplasma melliferum, showing that interdomain rotation is a rate-limiting step in polymerization.