Sequential MAVS- and MyD88/TRIF-signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes
L. Ghita, V. Breitkopf, F. Mulenge, A. Pavlou, O. L. Gern, V. Duran, C. K. Prajeeth, M. Kohls, K. Jung, M. Stangel, I. Steffen, U. Kalinke
This study identifies astrocytes as key IFN-β producers in TBEV-infected mice, showing biphasic IFN-β induction dependent on MAVS and later MyD88/TRIF signaling.
bioRxiv · Jun 30, 2020Immunology