A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma
N. Schleussner, P. Cauchy, V. Franke, M. Giefing, O. Fornes, N. Vankadari, S. Assi, M. Costanza, M. A. Weniger, A. Akalin, I. Anagnostopoulos, T. Bukur, M. G. Casarotto, F. Damm, O. Daumke, , R. Grosschedl
This study identifies a mutation in IRF4 that alters DNA-binding specificity and gene regulation in lymphoma, leading to disease-specific gene up-regulation.
bioRxiv · Dec 29, 2022 · PreprintCancer Biology