A. Rosenwald

Proteomic profiling identifies Serpin B9 as mediator of resistance to CAR T-cell and bispecific antibody treatment in B-cell lymphoma

A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma

This study identifies a mutation in IRF4 that alters DNA-binding specificity and gene regulation in lymphoma, leading to disease-specific gene up-regulation.

High-dimensional single-cell definition of CLL T cells identifies Galectin-9 as novel immunotherapy target

The paper defines CLL T cell subtypes and identifies Galectin-9 as a novel immunotherapy target through single-cell and multi-omics analyses.

Preclinical models of human multiple myeloma subgroups

This study generates preclinical models of human multiple myeloma subgroups by inducing specific genetic alterations in mice, showing their resemblance to human disease.

NOTCH1 drives immune-escape mechanisms in B cell malignancies

This study shows NOTCH1 mutations in B cell malignancies promote immune escape by upregulating PD-L1 and silencing HLA-class II, leading to poor clinical outcomes.