Author

V. Franke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 1

Frequent Co-Authors

A. Akalin· 5 shared D. Slade· 2 shared I. Grishkovskaya· 2 shared K. Djinovic-Carugo· 2 shared L.-M. Appel· 2 shared A. Baranovskii· 1 shared A. Ensser· 1 shared A. Kasiliauskaite· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

A. Akalin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma

N. Schleussner, P. Cauchy, V. Franke, M. Giefing, O. Fornes, N. Vankadari, S. Assi, M. Costanza, M. A. Weniger, A. Akalin, I. Anagnostopoulos, T. Bukur, M. G. Casarotto, F. Damm, O. Daumke, , R. Grosschedl

This study identifies a mutation in IRF4 that alters DNA-binding specificity and gene regulation in lymphoma, leading to disease-specific gene up-regulation.

bioRxiv · Dec 29, 2022 · PreprintCancer Biology

The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators

L.-M. Appel, I. Grishkovskaya, J. Benedum, V. Franke, A. Polyansky, A. Neudolt, A. Wunder, B. Zagrovic, A. Akalin, K. Djinovic-Carugo, D. Slade

bioRxiv · Feb 26, 2022 · PreprintBiochemistry

Identifying tumor cells at the single cell level

J. Dohmen, A. Baranovskii, B. Uyar, J. Ronen, V. Franke, A. Akalin

This paper introduces Ikarus, a machine learning pipeline that identifies tumor cells in single-cell data with high sensitivity and specificity across multiple datasets.

bioRxiv · Oct 15, 2021Cancer Biology

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expression

S. Walter, V. Franke, N. Drayman, E. Wyler, S. Tay, M. Landthaler, A. Akalin, A. Ensser, F. Full

This study shows herpesviruses induce DUX4 expression, which drives viral gene expression by mimicking embryonic genome activation.

bioRxiv · Mar 24, 2021 · PreprintMicrobiology

PHF3 regulates neuronal gene expression through the new Pol II CTD reader domain SPOC

L.-M. Appel, V. Franke, M. Bruno, I. Grishkovskaya, A. Kasiliauskaite, U. E. Schoeberl, M. G. Puchinger, S. Kostrhon, E. Beltzung, K. Mechtler, G. Lin, A. Vlasova, M. Leeb, R. Pavri, A. Stark, , D. Slade

This study identifies PHF3 as a CTD-binding factor that regulates neuronal gene expression by inhibiting Pol II elongation and mRNA stability.

bioRxiv · Feb 11, 2020Biochemistry