Evolution of chalcone isomerase from a non-catalytic ancestor
M. Kaltenbach, J. R. Burke, M. Dindo, A. Pabis, F. S. Munsberg, A. Rabin, S. C. L. Kamerlin, J. P. Noel, D. S. Tawfik
This study shows chalcone isomerase evolved from a non-catalytic ancestor through four founder mutations with weak epistasis, enabling enantioselective activity.
bioRxiv · Aug 10, 2017Biochemistry