M. Dindo

Engineered Oxalate decarboxylase boosts activity and stability for biological applications

This study engineers Oxalate decarboxylase to improve its activity and stability for medical applications in hyperoxaluria treatment.

Non-consecutive enzyme interactions within TCA cycle supramolecular assembly regulate carbon-nitrogen metabolism

The paper shows that non-consecutive TCA cycle enzymes MDH and ICD interact in droplets, enhancing ICD activity and affecting carbon-nitrogen metabolism in B. subtilis.

Chemotactic interactions drive migration of membraneless active droplets

The paper demonstrates that chemotactic interactions drive the migration of membraneless active droplets by generating pH gradients, enabling collective behavior and potential applications in synthetic biology.

Cryptic genetic variations of alanine:glyoxylate aminotransferase shape its fitness and dynamics

The paper investigates how genetic variations in AGT1 affect its conformational flexibility and fitness, revealing cryptic functions related to protein-protein interactions.

Sustained Enzymatic Activity and Flow in Crowded Protein Droplets

This paper demonstrates a system of protein droplets that sustain enzymatic activity and flow, mimicking cellular environments and metabolic processes.

Evolution of chalcone isomerase from a non-catalytic ancestor

This study shows chalcone isomerase evolved from a non-catalytic ancestor through four founder mutations with weak epistasis, enabling enantioselective activity.