Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells
S. Ganther, A. Radaic, N.-Y. N. Chang, C. Tafolla, L. Zhan, J. C. Fenno, Y. Kapila
This study shows T. denticola dentilisin activates TLR2/MyD88 to upregulate MMPs via Sp1, promoting tissue destruction in periodontal disease.
bioRxiv · Jan 18, 2021Microbiology