MicrobiologybioRxiv
Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells
S. Ganther, A. Radaic, N.-Y. N. Chang…·Y. Kapila
This study shows T. denticola dentilisin activates TLR2/MyD88 to upregulate MMPs via Sp1, promoting tissue destruction in periodontal disease.
DOI 10.1371/journal.ppat.1009311