Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent beta-catenin nuclear accumulation
A. Chocarro-Calvo, M. Jociles-Ortega, J. M. Garcia-Martinez, P. Louphrasitthiphol, Y. Vivas-Garcia, A. RAMIREZ-SANCHEZ, J. Chauhan, M. C. FIUZA, M. DURAN, C. GARCIA-JIMENEZ, C. GODING
The paper shows that MITFLow melanoma cells uptake fatty acids from adipocytes, activating AXL and CAV1 to drive beta-catenin nuclear accumulation, promoting invasion.
bioRxiv · Jan 21, 2024 · PreprintCancer Biology