SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells.
J. M. Garcia-Martinez, A. Chocarro-Calvo, J. Martinez-Useros, N. Regueira-Acebedo, M. J. Fernandez-Acenero, A. Munoz, M. J. Larriba, C. Garcia-Jimenez
This study shows that vitamin D inhibits the Wnt/β-catenin pathway in colon cancer cells by activating SIRT1, which deacetylates and excludes β-catenin from the nucleus, reducing tumor growth.
bioRxiv · Jan 21, 2024Cancer Biology