Spatial control of the APC/C ensures the rapid degradation of Cyclin B1
L. Cirillo, R. Young, S. Veerapathiran, A. Roberti, M. S. Martin, A. Abubacar, C. Perosa, C. Coates, R. Muhammad, T. I. Roumeliotis, J. Choudhary, C. Alfieri, J. Pines
The paper shows that spatial regulation of the APC/C at mitotic chromosomes enables rapid Cyclin B1 degradation, ensuring proper cell division and genomic stability.
bioRxiv · Oct 26, 2023Cell Biology