R. Young

The development of social attention in orangutans: comparing peering behaviour in wild and zoo-housed individuals

This study compares peering behavior in wild and zoo-housed immature Sumatran orangutans, finding similar age-related patterns but differences in target selection and frequency.

Protein codes promote selective subcellular compartmentalization

This study introduces ProtGPS, a protein language model that predicts subcellular compartment localization and identifies mutations affecting this process.

Spatial control of the APC/C ensures the rapid degradation of Cyclin B1

The paper shows that spatial regulation of the APC/C at mitotic chromosomes enables rapid Cyclin B1 degradation, ensuring proper cell division and genomic stability.

Spatial and temporal control of lysis by the lambda holin

The paper investigates the molecular basis of polar lysis in phage λ using time lapse fluorescence microscopy, finding that the holin forms two-dimensional rafts at cell poles before lysis.

Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling

This study functionally analyzes Cdc20's role in mitotic checkpoint signaling by identifying the CRY box's critical role in SAC through MCC formation and APC/C interaction.

Genome-wide CRISPRi knockdown to map gene essentiality landscape in coliphages {lambda} and P1

The paper uses CRISPRi to identify essential genes in coliphages λ and P1, revealing insights into gene essentiality and highlighting potential false positives in less studied phages.

Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State

The paper identifies a regulatory polymorphism in LMO1 that reduces neuroblastoma risk by preventing the adrenergic cell state in zebrafish and humans.

Long Noncoding RNA RROL Provides Chromatin Scaffold for MYC-WDR82 Interaction to Impact Lipid Metabolism and Tumor Cell Growth in Multiple Myeloma

This study identifies RROL as a therapeutically actionable lncRNA in multiple myeloma that supports tumor growth through chromatin scaffolding of MYC-WDR82 interaction.

Retinoic acid rewires the adrenergic core regulatory circuitry of neuroblastoma

This study shows retinoic acid reprograms enhancer landscapes in MYCN-amplified neuroblastoma cells, downregulating MYCN and inducing sympathetic differentiation.

Bursting out: linking changes in nano-topography and biomechanical properties of biofilm-forming Escherichia coli to T4 lytic cycle

This study investigates how T4 phage infection alters the nano-topography and biomechanics of biofilm-forming E. coli, revealing distinct lysis patterns compared to planktonic cells.

The effect of ocean warming on black sea bass (Centropristis striata) aerobic scope and hypoxia tolerance

This study examines how ocean warming affects the aerobic scope and hypoxia tolerance of black sea bass, finding that performance declines beyond 24°C despite maintained oxygen supply.

Phage-encoded cationic antimicrobial peptide used for outer membrane disruption in lysis

This study identifies a phage-encoded cationic antimicrobial peptide, Gp28, that disrupts bacterial outer membranes during lysis, functioning similarly to human antimicrobial peptides like LL-37.

The role of chromosomal inversions in speciation

This study reconstructs the evolutionary history of chromosomal inversions in D. persimilis and D. pseudoobscura, showing that inversions segregate before speciation and contribute to hybrid incompatibilities.