Spatio-temporal, optogenetic control of gene expression in organoids
I. Legnini, L. Emmenegger, A. Zappulo, R. Wurmus, A. Oliveras Martinez, C. Cerda Jara, A. Boltengagen, T. Hessler, G. Mastrobuoni, A. Rybak-Wolf, S. Kempa, R. P. Zinzen, A. Woehler, N. Rajewsky
This study uses optogenetic control to manipulate gene expression in organoids, demonstrating its ability to generate patterned tissue structures and reveal new insights into neurodevelopmental gene regulation.
bioRxiv · Sep 26, 2021 · PreprintBioengineering