S. Kempa

Intestinal interstitial fluid isolation provides novel insight into the human host-microbiome interface

The paper develops methods to collect intestinal interstitial fluid from different segments and shows segment-specific differences in microbiota-derived metabolites, cytokines, and proteins compared to plasma and serum.

L-Glyceraldehyde inhibits neuroblastoma cell growth via a multi-modal mechanism on metabolism and signaling

This paper identifies a multi-modal mechanism by which L-GA inhibits neuroblastoma cell growth through metabolic disruption, oxidative stress, and nucleotide biosynthesis inhibition.

Tissue protective role of Ganetespib in SARS-CoV-2-infected Syrian golden hamsters

This study shows that Ganetespib, an HSP90 inhibitor, reduces SARS-CoV-2 replication and inflammation in vitro and improves clinical outcomes in infected Syrian golden hamsters.

Spatio-temporal, optogenetic control of gene expression in organoids

This study uses optogenetic control to manipulate gene expression in organoids, demonstrating its ability to generate patterned tissue structures and reveal new insights into neurodevelopmental gene regulation.

Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage

This study quantifies how gut microbiota affects inflammation and organ damage in hypertension using germ-free and colonized mice, finding the kidney is more susceptible to microbial influence.

Integrative functional genomics decodes herpes simplex virus 1

This study decodes the complete HSV-1 transcriptome and translatome during lytic infection, identifying novel transcripts, ORFs, and regulatory elements.

The conserved histone chaperone LIN-53 links lifespan and healthspan regulation in C. elegans

This study shows LIN-53 links lifespan and healthspan in C. elegans by regulating chromatin and trehalose levels, with implications for evolutionary conservation.

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis

This study shows that non-canonical HIF-1 stabilization is crucial for intestinal tumorigenesis, independent of hypoxia, by affecting both epithelial and microenvironmental oncogenic processes.

Proteomic analysis of chemosensory organs in the honey bee parasite Varroa destructor: a comprehensive examination of the potential carriers for semiochemicals

This study identifies potential semiochemical carriers in Varroa destructor chemosensory organs through proteomic analysis.