MicrobiologybioRxiv
MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis
V. D. Menachery, L. E. Gralinski, H. D. Mitchell…·R. S. Baric
This study shows that disrupting MERS-CoV NSP16's 2O methyl-transferase activity attenuates viral pathogenesis and provides a live attenuated vaccine platform.