Author

K. Debbink

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:variant calling· 2

Frequent Co-Authors

V. D. Menachery· 5 shared A. L. Routh· 4 shared B. A. Johnson· 4 shared C. Schindewolf· 4 shared J. A. Plante· 4 shared K. S. Plante· 4 shared D. H. Walker· 3 shared K. Lokugamage· 3 shared

Activity by Year

2016-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

V. D. Menachery

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6 papers

Recent·Most cited

SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3

C. Schindewolf, K. Lokugamage, M. Vu, B. A. Johnson, D. Scharton, J. A. Plante, B. K. Kalveram, P. A. Crocquet-Valdes, S. L. Sotcheff, E. Jaworski, R. E. Alvarado, K. Debbink, M. D. Daugherty, S. Weaver, A. L. Routh, , V. D. Menachery

This paper shows that SARS-CoV-2's NSP16 protein helps evade immune detection by methylating viral mRNA, and disrupting this function reduces viral replication and disease in hamsters.

bioRxiv · Sep 26, 2022Microbiology

QTQTN motif upstream of the furin-cleavage site plays key role in SARS-CoV-2 infection and pathogenesis.

M. N. Vu, K. Lokugamage, J. A. Plante, D. Scharton, B. A. Johnson, S. Sotcheff, D. Swetnam, C. Schindewolf, R. E. Alvarado, P. A. Crocquet-Valdes, K. Debbink, S. Weaver, D. H. Walker, A. L. Routh, K. S. Plante, V. D. Menachery

This study shows that deleting the QTQTN motif reduces SARS-CoV-2 replication and disease by affecting spike processing and glycosylation.

bioRxiv · Dec 15, 2021Microbiology

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

A. Muruato, M. Vu, B. A. Johnson, M. Davis-Gardner, A. R. Vanderheiden, K. Lokugamage, C. Schindewolf, P. A. Crocquet-Valdes, R. M. Langsjoen, J. A. Plante, K. S. Plante, S. C. Weaver, K. Debbink, A. L. Routh, D. H. Walker, , V. D. Menachery

This study creates a mouse-adapted SARS-CoV-2 strain that protects mice from lethal SARS-CoV challenge, demonstrating cross-strain immunity.

bioRxiv · May 3, 2021Microbiology

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

B. A. Johnson, X. Xie, B. Kalveram, K. G. Lokugamage, A. Muruato, J. Zou, X. Zhang, T. Juelich, J. K. Smith, L. Zhang, C. Schindewolf, M. N. Vu, A. Vanderheiden, J. A. Plante, K. S. Plante, , V. D. Menachery

This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.

bioRxiv · Aug 26, 2020 · PreprintMicrobiology

MERS-CoV NSP16 necessary for IFN resistance and viral pathogenesis

V. D. Menachery, L. E. Gralinski, H. D. Mitchell, K. H. Dinnon, S. R. Leist, B. L. Yount, R. L. Graham, E. T. McAnarney, K. G. Stratton, A. S. Cockrell, K. Debbink, A. C. Sims, K. M. Waters, R. S. Baric

This study shows that disrupting MERS-CoV NSP16's 2O methyl-transferase activity attenuates viral pathogenesis and provides a live attenuated vaccine platform.

bioRxiv · Aug 8, 2017Microbiology

Vaccination has minimal impact on the intrahost diversity of H3N2 influenza viruses

K. Debbink, J. T. McCrone, J. G. Petrie, R. Truscon, E. Johnson, E. K. Mantlo, A. S. Monto, A. S. Lauring

This study examines the effect of seasonal influenza vaccination on intrahost diversity of H3N2 viruses using whole genome sequencing and finds minimal impact.

bioRxiv · Nov 7, 2016Microbiology