Fuse to defuse: a self-limiting ribonuclease-ring nuclease fusion for type III CRISPR defence
A. Samolygo, J. S. Athukoralage, S. Graham, M. F. White
The paper describes a fusion protein combining a ribonuclease and a ring nuclease to regulate cOA signaling in type III CRISPR systems, ensuring a time-limited immune response.
bioRxiv · Mar 11, 2020Biochemistry