Soluble ECM promotes organotypic formation in lung alveolar model
J. C. Valdoz, N. A. Franks, C. G. Cribbs, D. J. Jacobs, E. L. Dodson, C. J. Knight, P. D. Poulson, S. R. Garfield, B. C. Johnson, B. M. Hemeyer, M. T. Sudo, J. A. Saunooke, B. C. Kartchner, A. Saxton, M. L. Vallecillo-Zuniga, , P. M. Van Ry
This study shows that adding soluble ECM to suspension culture enables the formation of organotypic lung structures from stable cell lines, including lumen-like airspaces and vasculature, and models lung fibrosis with drug testing capabilities.
bioRxiv · Sep 16, 2021Bioengineering