A. Sellam

Manganese homeostasis modulates fungal virulence and stress tolerance in Candida albicans

This study investigates how manganese homeostasis affects virulence and stress tolerance in Candida albicans through transcriptional profiling and genetic analysis.

Transcriptional control of hypoxic hyphal growth in the fungal pathogen Candida albicans

This study identifies Ahr1 and Tye7 as negative regulators of hypoxic filamentation in C. albicans through genetic and genomic analyses.

Transcriptome analysis uncovers a link between copper metabolism, and both fungal fitness and antifungal sensitivity in the opportunistic yeast Candida albicans

The paper uses RNA-seq to analyze how copper levels affect gene expression in Candida albicans, revealing links to fungal fitness and antifungal sensitivity.

A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen Candida albicans

This study identifies Snf5 as a key regulator linking oxygen status to metabolic flexibility, commensalism, and virulence in Candida albicans.

Dot6 is a major regulator of cell size and a transcriptional activator of ribosome biogenesis in the opportunistic yeast Candida albicans

The paper identifies Dot6 as a key regulator of cell size and ribosome biogenesis in Candida albicans, showing its role in integrating growth signals via the TOR pathway.

A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion

This paper identifies halogenated salicylanilides as antivirulence agents against Candida species, showing inhibition of morphogenesis, biofilm formation, and host cell invasion.