C. Garcia

Supervised Automation of Cell Counting in Confocal Microscopic Cochlear Imaging Datasets Using Macro in Imaris

The paper develops a supervised automation protocol in Imaris to streamline cell counting in confocal cochlear images, reducing manual effort and human error.

A comparison among EL-FAME, PLFA, and quantitative PCR methods to detect changes in the abundance of soil bacteria and fungi

The paper compares EL-FAME, PLFA, and qPCR methods for quantifying soil microbial abundances and finds EL-FAME and PLFA are more reliable than qPCR, with PLFA better for detecting small changes in forest soils.

Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas

This study identifies a rare pancreatic tissue-resident regulatory T cell population that exhibits both anti-tumour and pro-repair functions in the exocrine pancreas.

Phylogenomic evidence for host specialization and genetic divergence in OsHV-1 infecting Magallana gigas and Ostrea edulis

This study analyzes OsHV-1 genomes from two oyster species to show host-driven genetic divergence and cross-species transmission.

Impairment of autophagy-lysosomal activity near the chronically implanted microelectrodes

This study investigates how long-term microelectrode implantation impairs autophagy-lysosomal activity, leading to tissue degeneration near the implant.

Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia

This study shows resident macrophages improve cardiac remodelling while recruited macrophages influence infarct size after myocardial ischemia/reperfusion injury.

DNA primase large subunit is an essential plant gene for geminiviruses, putatively priming viral ss-DNA replication

This study identifies the DNA primase large subunit (PRiL) as essential for geminiviral DNA replication in plants, showing that mutations in PRiL confer resistance to ToLCNDV.

Identification of leukemia-associated immunophenotypes by database-guided flow cytometry provides a highly sensitive and reproduciblestrategy for the study of measurable residual disease in acutemyeloblastic leukemia

This study identifies leukemia-associated immunophenotypes using database-guided flow cytometry, enabling sensitive and reproducible monitoring of measurable residual disease in acute myeloid leukemia.

Proposal and extensive test of a calibration protocol for crop phenology models

This paper proposes and tests a calibration protocol for crop phenology models, reducing prediction error and team variability by 22%.

Emergence and clonal expansion of Vibrio aestuarianus lineages pathogenic for oysters in Europe

The paper investigates the emergence and clonal expansion of V. aestuarianus francensis lineages in Europe by analyzing genome sequences from environmental samples and showing evidence of selective bottlenecks and copper resistance islands.

Heparins enhance C1 esterase inhibitor activity: a promising remedy for acute hereditary angioedema

This study shows low-molecular weight heparins enhance C1-INH activity in HAE patients and in vitro, suggesting they could be a cost-effective treatment for acute HAE.

Ex vivo and in vivo evidence that cigarette smoke-exposed T regulatory cells impair host immunity against Mycobacterium tuberculosis

This study shows that cigarette smoke-exposed T regulatory cells impair macrophage control of Mycobacterium tuberculosis infection in vitro and in vivo.

Insight in the quorum sensing-driven lifestyle of the non-pathogenic Agrobacterium tumefaciens 6N2 and the interactions with the yeast Meyerozyma guilliermondii

This study investigates the quorum sensing (QS) systems of nonpathogenic Agrobacterium tumefaciens 6N2 and its interactions with the yeast Meyerozyma guilliermondii, revealing QS-regulated protein differences in pure and dual cultures.

Does male mate choice select for female colouration in a promiscuous primate species?

This study investigates whether male mate choice in Japanese macaques is influenced by female skin coloration, finding no preference for darker/redder females and no use of coloration to assess fertility or social status.

Screening of Cultivars for Tissue Culture Response and Establishment of Genetic Transformation in a High-yielding and Disease-resistant Cultivar of Theobroma cacao

The paper establishes tissue culture and genetic transformation methods for a high-yielding, disease-resistant Theobroma cacao cultivar and identifies factors improving T-DNA delivery and somatic embryogenesis.

Tuning TPO-R signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia

This study develops diabody ligands that modulate TPO-R signaling, showing partial agonists preserve HSCs and inhibit ET oncogenesis.

The chaos in calibrating crop models

The paper proposes a method to develop calibration guidelines for system models by analyzing multi-model simulations, applying it to crop model phenology calibration and providing recommendations on objective functions, parameters, and software.

Fine-tuning of Epithelial EGFR signals Supports Coordinated Mammary Gland Development

This study shows that Rasgrp1 fine-tunes EGFR signals in mammary epithelial cells to regulate development during puberty, with in vitro and in vivo effects on proliferation, branching, and cellularity.

How well do crop modeling groups predict wheat phenology, given calibration data from the target population?

This study evaluates how well 27 crop modeling groups predict wheat phenology in Northern France using calibration data from the same target population, finding mean absolute errors comparable to measurement error.

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma

This study shows obesity accelerates pancreatic cancer by altering the tumor microenvironment, with reversible effects through weight loss.

Splicing inhibition enhances the antitumor immune response through increased tumor antigen presentation and altered MHC-I immunopeptidome

This study shows that splicing inhibition with IP2 enhances antitumor immunity by increasing antigen presentation and altering MHC-I immunopeptidomes.

A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion

This paper identifies halogenated salicylanilides as antivirulence agents against Candida species, showing inhibition of morphogenesis, biofilm formation, and host cell invasion.

First natural crossover recombination of intact ORFs between two distinct species of the family Closteroviridae

The paper identifies LCV-SP as the first natural crossover recombination of intact ORFs between two Closteroviridae species, showing recombination's role in viral evolution.

Daam2 Driven Degradation Of VHL Promotes Gliomagenesis

The paper identifies Daam2 as a factor promoting glioma formation by suppressing VHL expression through ubiquitination and degradation.