Author

A. Shea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Organism:E. coli· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Bruna· 2 shared A. E. Frick-Cheng· 2 shared H. L. T. Mobley· 2 shared S. N. Smith· 2 shared A. Allo Anido· 1 shared A. G. Martin· 1 shared A. Giovannetti· 1 shared A. Nagano· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

A. Bruna

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Environment-Dependent Modes of Adaptive Evolution in Neuroblastoma: Plasticity as a Selectable Trait

C. Roux, S. Hamer, A. Shea, E. Chen, A. S. Sadr, C. English, A. Allo Anido, H. Che, B. Geoerger, L. Chesler, G. Schleiermacher, M. D. Morgan, A. Bruna

This study identifies three modes of plasticity in neuroblastoma that shape tumour evolution under selective pressures and therapy resistance.

bioRxiv · Dec 7, 2023 · PreprintCancer Biology

Altered motility in response to iron-limitation is regulated by lpdA in uropathogenic E. coli CFT073

A. E. Frick-Cheng, A. Shea, J. R. Roberts, S. N. Smith, M. Ohi, H. L. T. Mobley

This study shows that lpdA regulates iron-mediated motility in UPEC, which impacts virulence under iron-limited conditions.

bioRxiv · Sep 27, 2023 · PreprintMicrobiology

Modelling drug responses and evolutionary dynamics using triple negative breast cancer patient-derived xenografts

A. Shea, Y. Eyal-Lubling, D. Guerrero-Romero, R. Manzano Garcia, W. Greenwood, M. O'Reilly, D. Georgopoulou, M. Callari, G. Lerda, S. Wix, A. Giovannetti, R. Masina, E. Esmaeilishirazifard, A. G. Martin, A. Nagano, , A. Bruna

This paper uses TNBC patient-derived xenografts to model drug responses and evolutionary dynamics, revealing a novel mechanism of olaparib response and synergistic effects with salinomycin.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

Phenotypic Assessment of Clinical Escherichia coli Isolates Predicts Uropathogenic Potential

A. Shea, A. E. Frick-Cheng, S. N. Smith, H. L. T. Mobley

This study uses phenotypic assays to predict uropathogenic potential of Escherichia coli isolates from UTI cases, showing that certain phenotypes correlate with infection severity.

bioRxiv · Aug 31, 2022Microbiology