RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppression
A. Bleve, F. M. Consonni, M. Incerti, V. Garlatti, C. Pandolfo, M. N. Monari, S. Serio, D. Pistillo, M. Sironi, C. Ali, M. Manfredi, G. Finocchiaro, C. Panico, G. Condorelli, A. Sica
This study shows RORγ mediates cancer-driven lipid dysmetabolism and myeloid immunosuppression by promoting MDSC expansion and M2 TAM polarization, with cholesterol lowering reversing these effects.
bioRxiv · Nov 19, 2023Immunology