M. Sironi

RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppression

This study shows RORγ mediates cancer-driven lipid dysmetabolism and myeloid immunosuppression by promoting MDSC expansion and M2 TAM polarization, with cholesterol lowering reversing these effects.

SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress and autophagic flow

This study identifies ORF3c as a SARS-CoV-2 protein that disrupts mitochondrial metabolism, increases oxidative stress, and blocks autophagy, potentially contributing to disease progression.

Variola virus is as old as the earliest historical lines of evidence suggest

The paper estimates the emergence of variola virus (VARV) to be earlier than 3,800 years ago, resolving a debate between molecular dating and historical records.

Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3

This study investigates the role of PTX3 in regulating inflammation and resistance to invasive pneumococcal infection in mice and humans, finding that PTX3 deficiency increases susceptibility and enhances neutrophil inflammation.

Substrate Recognition by γ-Glutamyltransferase: A Molecular Dynamics Simulations Study

This study uses molecular dynamics simulations to investigate how Escherichia coli GGT recognizes glutamine, identifying structural motifs and conformational dynamics that govern substrate binding.

Simplexviruses successfully adapt to their host by fine-tuning immune responses

This study identifies positive selection in herpes simplex virus glycoproteins that influence immune escape mechanisms and HLA-G expression, explaining their adaptation to hominins.

Antigenic variation of SARS-CoV-2 in response to immune pressure

The paper analyzes SARS-CoV-2 genome diversity to show that B cell epitopes are more variable than non-epitope regions, while T cell epitopes show reduced variability, suggesting immune evasion strategies.