Human Cytomegalovirus antagonizes activation of Fcγ receptors II and III by distinct and synergizing modes of IgG manipulation
P. Kolb, K. Hoffmann, A. Sievert, H. Reinhard, E. Merce-Maldonado, V. T. K. Le-Trilling, D. Guetle, H. Hengel
This paper shows HCMV uses gp34 and gp68 to block FcγR activation by different mechanisms that work together to evade antibody-mediated immunity.
bioRxiv · Oct 12, 2020Microbiology