K. Hoffmann

Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity

This study identifies quinoxaline-based anti-schistosomal compounds with potent anti-malarial activity against Plasmodium falciparum, including resistance mechanisms involving pfqrp1 and pfatp2.

Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity

This study identifies and characterizes Rhesus CMV-encoded Fcγ-binding glycoproteins, showing they delay antibody-mediated immune control during primary infection.

Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line

The paper shows that B.1.1.7 and B.1.617.2 SARS-CoV-2 variants have a replication advantage over B.1 in ACE2-deficient lung cells, suggesting reliance on alternative cellular factors.

Human Cytomegalovirus antagonizes activation of Fcγ receptors II and III by distinct and synergizing modes of IgG manipulation

This paper shows HCMV uses gp34 and gp68 to block FcγR activation by different mechanisms that work together to evade antibody-mediated immunity.

Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni.

This paper identifies and validates the presence of G-quadruplexes (G4) in the Schistosoma mansoni genome and demonstrates their enrichment in specific genomic regions and pathways.

Preservation of stemness in high-grade serous ovarian cancer organoids requires low Wnt environment

This study shows that HGSOC organoids require a low Wnt environment for growth, similar to genetically altered FT organoids, indicating early niche changes support tumor outgrowth.

Mutations in nucleoporin NUP88 cause lethal neuromuscular disorder

This study identifies biallelic NUP88 mutations as a cause of lethal fetal akinesia deformation sequence (FADS) and shows their effects on neuromuscular development in zebrafish and human cells.