Engineering T cell resistance to HIV-1 infection via knock-in of peptides from the heptad repeat 2 domain of gp41
A. Maslennikova, N. Kruglova, S. Kalinichenko, D. Komkov, M. Shepelev, D. Golubev, A. Siniavin, A. Vzorov, A. Filatov, D. Mazurov
This paper develops a CRISPR/Cas9-based method to knock-in HIV-1 inhibitory peptides into T cells, enhancing resistance to HIV-1 infection.
bioRxiv · Apr 30, 2021Microbiology