Epitope Engineered Human Haematopoietic Stem Cells are Shielded from CD123-targeted Immunotherapy
R. Marone, E. Landmann, A. Devaux, R. Lepore, D. Seyres, J. Zuin, T. Burgold, C. Engdahl, G. Capoferri, A. DellAglio, C. Larrue, F. Simonetta, J. Rositzka, M. Rhiel, G. Andrieux, , L. T. Jeker
This paper shows that epitope-engineered human hematopoietic stem cells are protected from CD123-targeted immunotherapy while maintaining functionality, offering a strategy for tumor-selective therapy.
bioRxiv · Jul 11, 2023Bioengineering