Author

F. Simonetta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 3 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. Baker· 4 shared R. S. Negrin· 4 shared J. K. Lohmeyer· 2 shared K. Maas-Bauer· 2 shared T. Hirai· 2 shared X. Ji· 2 shared A. Aalipour· 1 shared A. Camus· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

J. Baker

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Epitope Engineered Human Haematopoietic Stem Cells are Shielded from CD123-targeted Immunotherapy

R. Marone, E. Landmann, A. Devaux, R. Lepore, D. Seyres, J. Zuin, T. Burgold, C. Engdahl, G. Capoferri, A. DellAglio, C. Larrue, F. Simonetta, J. Rositzka, M. Rhiel, G. Andrieux, , L. T. Jeker

This paper shows that epitope-engineered human hematopoietic stem cells are protected from CD123-targeted immunotherapy while maintaining functionality, offering a strategy for tumor-selective therapy.

bioRxiv · Jul 11, 2023Bioengineering

Single-cell Transcriptomics Reveal Different Maturation Stages and Sublineages Commitment of Human Thymic Invariant Natural Killer T cells

K. Maas-Bauer, S. Acharya, J. Baker, D. B. Lewis, R. S. Negrin, F. Simonetta

This study uses single-cell RNA sequencing to identify maturation stages and sublineage commitment in human thymic iNKT cells, revealing two distinct clusters with immature and mature profiles.

bioRxiv · Aug 10, 2022Cell Biology

Integrated Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of Acute Graft-versus-Host-Disease

J. K. Lohmeyer, T. Hirai, M. Turkoz, S. Buhler, T. L. Ramos, N. Koehler, J. Baker, X. Ji, J. Villard, Y. Chalandon, F. Simonetta, R. S. Negrin

This study identifies how regulatory T cells suppress acute graft-versus-host disease by modulating conventional T cell transcriptomes and metabolism without affecting graft-versus-tumor activity.

bioRxiv · Jul 26, 2022 · PreprintImmunology

Multi-parameter optical imaging of immune cell activity in chimeric antigen receptor T-cell and checkpoint blockade therapies

J. Xie, F. E. Rami, K. Zhou, F. Simonetta, Z. Chen, X. Zheng, M. Chen, P. B. Balakrishnan, S.-Y. Dai, S. Murty, I. S. Alam, J. Baker, R. S. Negrin, S. S. Gambhir, J. Rao

The paper develops a small molecule for imaging immune cell activity in cancer immunotherapies and demonstrates its utility in predicting treatment outcomes.

bioRxiv · Oct 11, 2021 · PreprintImmunology

Allogeneic CAR-invariant Natural Killer T Cells Exert Potent Antitumor Effects Through Host CD8 T cell Cross-Priming

F. Simonetta, J. K. Lohmeyer, T. Hirai, K. Maas-Bauer, M. Alvarez, A. S. Wenokur, J. Baker, A. Aalipour, X. Ji, S. Haile, C. L. Mackall, R. S. Negrin

This study shows allogeneic CAR-iNKT cells effectively combat tumors in mice by directly attacking cancer cells and boosting host CD8 T cell responses, even across major MHC barriers.

bioRxiv · Feb 3, 2021Immunology