Grubraw, a chemogenetic mitochondrial activator, reveals new mechanisms underlying the Warburg effect
E. S. Potekhina, D. Y. Bass, A. V. Ivanenko, A. A. Moshchenko, D. A. Korzhenevskiy, E. Shevchenko, A. E. Karnaeva, N. F. Zakirova, A. V. Ivanov, L. E. Shimolina, M. V. Shirmanova, O. V. Lyang, O. I. Patsap, O. M. Kudryashova, G. R. Gazizova, , V. Belousov
The paper introduces Grubraw, a chemogenetic tool that activates mitochondrial respiration in Warburg-type cancer cells, revealing that mitochondrial pyruvate export and reduced proliferation occur.
bioRxiv · Apr 18, 2023 · PreprintCancer Biology