Contribution of 6mer seed toxicity to HIV-1 induced cytopathicity
A. Vaidyanathan, H. E. Taylor, T. J. Hope, R. T. D'Aquila, E. T. Bartom, J. F. Hultquist, M. E. Peter
This paper identifies HIV-encoded miRNA HIV-miR-TAR-3p as a cytotoxic factor that induces cell death via DISE through a noncanonical 6mer seed, revealing a mechanism for HIV-induced cytopathicity.
bioRxiv · Oct 1, 2022 · PreprintMicrobiology