E. T. Bartom

Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: a novel path to cancer prevention

This study shows licochalcone A suppresses breast cancer growth by targeting SREBP1-dependent lipogenesis and inflammation.

Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemia.

This study shows that E2a suppresses T-ALL by promoting T cell development and inter-thymocyte competition, preventing leukemogenesis.

TGF-β promotes the postselection thymic development and peripheral function of interferon-γ-producing iNKT cells

This study shows TGF-β is required for thymic iNKT1 cell development and adhesion receptor expression, but not for liver iNKT1 cell function.

CD95/Fas ligand mRNA is toxic to cells through more than one mechanism

This study shows CD95L mRNA induces toxicity through multiple mechanisms, including DISE and Ago-dependent RNAi, with varying dependence on Ago proteins across cell lines.

Contribution of 6mer seed toxicity to HIV-1 induced cytopathicity

This paper identifies HIV-encoded miRNA HIV-miR-TAR-3p as a cytotoxic factor that induces cell death via DISE through a noncanonical 6mer seed, revealing a mechanism for HIV-induced cytopathicity.

Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in a Murine Model of T Acute Lymphoblastic Leukemia

This study shows that the timing of Lef1 mutations in a murine T-ALL model affects its role as a tumor suppressor or oncogene, highlighting the importance of mutational order in leukemogenesis.

Identification of the toxic 6mer seed consensus in human cancer cells

The paper identifies GGGGGC as the most toxic 6mer seed in human cancer cells, confirming its mechanism through targeted gene disruption and reporter assays.

6mer seed toxicity in viral microRNAs

The paper identifies 6mer seed toxicity in viral miRNAs, showing some v-miRNAs kill cells via G-rich 6mer sequences, unlike most cellular miRNAs.

The oncogenic Kaposi sarcoma-associated herpesvirus encodes a mimic of the tumor suppressive miR-15/16 miRNA family

This study identifies KSHV miR-K6-5p as a functional mimic of the tumor suppressive miR-15/16 family, showing it inhibits cell cycle progression and promotes growth in KSHV-transformed B cells.

CD95/Fas ligand mRNA is toxic to cells

The paper shows that full-length CD95L mRNA is toxic to cells and induces apoptosis through sRNA processing independent of Dicer and Drosha, suggesting a new role for RNAi in cell fate regulation.

6mer seed toxicity in tumor suppressive microRNAs

The paper identifies 6mer seed sequences in miRNAs that are toxic to cancer cells, showing that tumor suppressive miRNAs use these toxic seeds to kill cancer cells.

Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

The paper shows that siRNAs based on CAG TNRs are toxic to cancer cells and slow tumor growth in a mouse model without toxicity.