Pro-drug peptide and its metabolites disrupt amyloid fibrils by destabilizing salt bridge interaction and planar beta-sheet topology
A. Vasista, B. Mandal, K. Anki Reddy
This study uses molecular dynamics simulations to show that Pro-Drug peptide and its metabolites disrupt Aβ aggregates by breaking salt bridges and altering hydrogen bonding patterns.
bioRxiv · Sep 9, 2020 · PreprintBiophysics