Novel allosteric mechanism of p53 activation by small molecules for targeted anticancer therapy
J. Zawacka-Pankau, V. V. Grinkevich, M. Burmakin, A. Vema, K. Fawkner, N. Issaeva, V. Andreotti, E. R. Dickinson, E. Hedstrom, C. Spinnler, A. Inga, L.-G. Larsson, A. Karlen, O. Tarasova, V. Poroikov, , G. Selivanova
This study identifies a novel allosteric mechanism by which small molecules activate p53 by blocking MDM2/MDMX binding, offering a new approach for anticancer therapy.
bioRxiv · Dec 7, 2018 · PreprintCancer Biology