J. Zawacka-Pankau

This study shows that Protoporphyrin IX inhibits p53/MDM2 and p53/MDM4 interactions, stabilizes p53 and TAp73, and induces apoptosis in B-cell chronic lymphocytic leukaemia cells without harming normal cells.

This paper identifies PpIX and BPD as compounds that activate TAp73 and inhibit TrxR1, inducing apoptosis in pancreatic cancer cells through a drug-repurposing approach.

The paper shows that protoporphyrin IX stabilizes and activates TAp73, inducing apoptosis in TP53-deficient cancer cells by disrupting interactions with MDM2/MDMX and inhibiting degradation by Itch.

This study identifies cysteine residues 124 and 277 as key targets of APR-246 for reactivating mutant p53 and restoring its tumor suppressor function in cancer cells.