Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions
G. E. Seabright, C. A. Cottrell, M. J. van Gils, A. D'addabbo, D. J. Harvey, A.-J. Beherns, J. D. Allen, Y. Watanabe, A. Maker, S. Vasiljevic, N. de Val, R. W. Sanders, A. B. Ward, M. Crispin
The paper investigates how HIV-1 envelope glycan networks affect the formation and stability of broadly neutralizing antibody epitopes, showing their importance in immunogen design.
bioRxiv · Feb 21, 2020Immunology