Y. Watanabe

Flow zoometry of Drosophila

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

A Tetravalent Dengue Virus-like Particle Vaccine Induces High levels of Neutralizing Antibodies and Inhibits Dengue Replication in Non-Human Primates

A tetravalent dengue VLP vaccine induces neutralizing antibodies and reduces viral replication in non-human primates without ADE.

MpmiR319 promotes gemma/gemma cup formation in the Liverwort Marchantia polymorpha

This study shows MpmiR319 suppresses MpRKD to regulate gemma and gemma cup formation in Marchantia polymorpha.

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice

The cholesterol pathway of the Golgi stress response induces cell death and transcription of Golgi-related genes through metabolic dysregulation of phosphatidylinositol-4-phosphate

Downregulation of CYP7B1 caused by lipotoxicity associates with the progression of non-alcoholic steatohepatitis

This study shows that restoring CYP7B1 expression reduces NASH progression in mice, linking its downregulation to lipid and oxidative stress in the early stages of the disease.

Intestelligence: A pharmacological neural network using intestine data

This paper develops a neural network using pharmacological data from guinea pig ilea to improve image classification accuracy.

Physicochemical properties of the vacuolar membrane and cellular factors determine formation of vacuolar invaginations

The paper shows that vacuolar invaginations in yeast result from changes in membrane physicochemical properties and cellular factors like Hfl1 and the ESCRT machinery.

Lassa virus glycoprotein nanoparticles elicit a neutralizing antibody that defines a new site of vulnerability

This study develops Lassa virus glycoprotein nanoparticles that stabilize GPC trimers and elicit neutralizing antibodies targeting a new vulnerability site.

Site-specific steric control of SARS-CoV-2 spike glycosylation

The paper compares glycosylation patterns of recombinant SARS-CoV-2 spike proteins across labs with infectious virus S protein, finding conserved site-specific glycan maturation stalling linked to protein structure.

The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation

This study shows that Ror1/2 receptors are essential for cardiac myofibroblast differentiation and heart remodeling in response to pressure overload.

Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine

This study characterizes the structure, conformation, and glycosylation of the SARS-CoV-2 spike protein expressed by the ChAdOx1 nCoV-19/AZD1222 vaccine, confirming its native-like properties.

Impaired phosphatidylethanolamine metabolism activates a reversible stress response that detects and resolves mutant mitochondrial precursors

The paper investigates the subcellular localization of Psd1 and shows that impaired phosphatidylethanolamine metabolism triggers an ER-assisted response to resolve nonfunctional mitochondrial precursors.

Modern Japanese ancestry-derived variants revealed the formation process of the current Japanese regional gradations

The paper identifies Jomon-derived genetic variants in modern Japanese populations and shows regional differences in admixture proportions and phenotypic traits.

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

This paper develops a two-component spike nanoparticle vaccine that protects macaques from SARS-CoV-2 infection by inducing strong neutralizing antibodies and reducing viral replication.

Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae

This study traces the emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae by analyzing genome sequences from multiple countries and time periods, revealing recombination events and antibiotic-driven mutations.

The histidine phosphotransfer AHP4 plays a negative role in Arabidopsis plant response to drought

This study shows AHP4 negatively regulates Arabidopsis drought response by modulating gene expression related to stress tolerance mechanisms.

Three-dimensional understanding of the morphological complexity of the human uterine endometrium

This study uses 3D imaging to reveal the complex morphology of human endometrial glands and their pathological features in adenomyosis.

Site-specific analysis of the SARS-CoV-2 glycan shield

The paper uses mass spectrometry to analyze glycan structures on the SARS-CoV-2 spike protein, revealing differences from host glycan processing and implications for vaccine design.

Lab-on-a-graphene-FET detection of key molecular events underpinning influenza virus infection and effect of antiviral drugs

This study uses graphene-FETs to detect molecular events during influenza infection and monitor antiviral drug effects in real-time.

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

The paper investigates how HIV-1 envelope glycan networks affect the formation and stability of broadly neutralizing antibody epitopes, showing their importance in immunogen design.

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

This study identifies vulnerabilities in coronavirus glycan shields by showing that MERS S protein has under-processed oligomannose-type glycan clusters, unlike SARS and HKU1 CoVs, and that these glycans do not form an effective shield against antibodies.

Novel application method for mesenchymal stem cell therapy utilizing its attractant-responsive accumulation property

This study demonstrates that delivering mesenchymal stem cells (MSCs) in a collagen gel scaffold enhances their migration to damaged sites and promotes wound healing without systemic side effects.

A miniaturized threshold-triggered acceleration data-logger for recording burst movements of aquatic animals

This paper introduces a threshold-triggered acceleration data-logger to selectively record burst movements of aquatic animals, demonstrating its effectiveness in both lab and field settings.