Fine mapping of PTSD GWAS reveals a role for amygdala Foxp2 in regulation of fear and threat responses
Olga Y. Ponomareva, Lauren T. Seabrook, Mateo Maya-Martínez, Claudia Klengel, Vijetha Balakundi, Sneha Kini, Ella Catt, John Zion, Radha Shah, Paloma Martinez Gonzalez, Emily Hernandez, Zoe G. Beatty, Malvina Millet, Quilla C. Flanagan-Burt, AA Lussier, , Kerry James Ressler
This study fine-maps PTSD GWAS data with amygdala eQTLs and shows FOXP2 expression is linked to increased PTSD risk, with functional validation in mice and humans.
bioRxiv · Jun 26, 2026 · PreprintNeuroscience