Assembly of branched chain amino acid (BCAA) to toxic fibrils may be related to pathogenesis of Maple syrup urine disease (MSUD)
Chandra Kanth P., Monisha Patel, Raj Dave, Ankur Singh, Viral Khatri, Aayushi Joshi, Sujoy Bandyopadhyay, Manoj Kumar Pandey, Dhiraj Devidas Bhatia, Nidhi Gour
This study investigates the aggregation of branched chain amino acids (BCAAs) in Maple syrup urine disease (MSUD) and finds they form amyloid-like fibrils with cytotoxic effects.
ChemBioChem · May 27, 2025Peer-reviewedBioengineering